St Jude device lowers blood pressure in small study
















(Reuters) – St Jude Medical Inc said on Monday its procedure that deadens nerves near the kidneys helped lower blood pressure in a small study of patients whose hypertension could not be controlled with drugs.


Patients in the study who were treated with the Enlightn renal denervation system saw an average reduction of 28 points in systolic blood pressure, which is the first number expressed in a reading, after 30 days. At six months, the 46 patients who received the treatment maintained an average systolic blood pressure reduction of 26 mmHg points.













The results were presented at the annual meeting of the American Heart Association in Los Angeles.


Patients enrolled in the study had an average blood pressure of 176/96 mmHg despite being treated with multiple medications to manage the condition. No serious side effects were reported, St Jude said.


Normal blood pressure is below 120/80 mmHg. Hypertension, or high blood pressure, is a reading above 140/90 mmHg.


Renal denervation is a procedure in which a thin, flexible catheter is threaded through the body to the renal sympathetic nerves near the kidneys. Radiofrequency energy is delivered to disrupt the nerve activity, relieving high blood pressure.


Millions of people have hypertension that is resistant to drugs, putting them at risk of heart attacks and stroke.


The new therapy is not yet approved in the United States, but several products are already available in Europe.


Device makers that have already received approval to sell hypertension devices in Europe include Medtronic, the front-runner, St Jude, Covidien, ReCor Medical and Vessix Vascular.


St Jude shares were up 29 cents, or less than 1 percent, at $ 38.80 in afternoon trading on the New York Stock Exchange.


(Reporting By Susan Kelly and Debra Sherman in Chicago; Editing by Gerald E. McCormick, Leslie Adler and Jim Marshall)


Medications/Drugs News Headlines – Yahoo! News



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Ahead of the Bell: Express Scripts plummets
















NEW YORK (AP) — Shares of Express Scripts slid in premarket trading Tuesday after the pharmacy benefits manager warned that persistent high joblessness and economic uncertainty would make 2013 more challenging, and expectations of Wall Street analysts were too high.


Pharmacy benefits managers, or PBMs, run prescription drug plans for employers, insurers and other customers. They process mail-order prescriptions and handle bills for prescriptions filled at retail pharmacies.













The St. Louis company handles more than a billion prescriptions each year after the $ 29.1 billion acquisition of a rival, Medco, in April.


Analysts were disappointed by the company’s outlook. Investors will now question whether Express Scripts benefits as much from recent acquisitions as the company had led them to believe, said Citi analyst George Hill, calling the company’s forecast “baffling.”


Express Scripts had lifted its 2012 earnings forecast in August after recording better-than-expected savings from its combination with Medco.


Jefferies analyst Brian Tanquilut lowered his rating on Express Scripts to “Hold” from “Buy” and cut his price target on the shares by $ 14 to $ 56.


Shares of Express Scripts Holding Co. dropped $ 8.25, or 13 percent, to $ 54.63 before the opening bell. The stock was up 41 percent so far this year through Monday’s trading.


Economy News Headlines – Yahoo! News



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The app’s the thing as Shakespeare goes digital
















TORONTO (Reuters) – William Shakespeare‘s plays are getting a 21st century-style makeover in the form of new apps for tablets and smart phones nearly 500 years after the Bard took pen to parchment.


Plays such as “Romeo and Juliet” and “Macbeth” spring to life in iPad apps released by Cambridge University Press, which pairs the texts with audio performances, commentary and other interactive content, transforming the classic plays for the digital age.













The apps are part of a new series called Explore Shakespeare that was introduced by the British publishing house to expand the playwright’s reach to casual readers.


“A lot of people have a copy of Shakespeare on their bookshelf that they never got around to reading because they have this idea that Shakespeare is hard or has to be studied to be appreciated,” said John Pettigrew, executive producer of the Explore Shakespeare series.


Pettigrew believes the plays are meant to be enjoyed and are accessible provided readers are given context to overcome outdated or poetic language.


While the core focus of the app is on the actual text, readers can consult glossaries, notes, photos and synopses at any point in the script.


“Everything there is designed to keep you in the play and to put you in the mind of the actor, director or writer,” he explained.


To understand less common language, readers can tap on words and phrases to delve into their meaning.


“A classic one is in ‘Romeo and Juliet‘ which is `wherefore art thou Romeo?’ It’s not ‘where are you Romeo?’, It’s `why are you Romeo?` So that kind of phrase gets a glossary to explain what is meant,” said Pettigrew.


The apps also include full audio performances from stars such as Kate Beckinsale and Martin Sheen. Other features help readers to visualize relations between actors in a scene, understand how Shakespeare interweaves themes throughout the play, and to analyze the text more thoroughly.


“You can delve into the language or themes or interpretation, but our first task is to show that it’s just a good story,” Pettigrew said.


Although the app was designed with consumers in mind, Pettigrew believes it could also play a role in education, with students embracing the app over its print counterpart.


“For a 13-year old, Shakespearean language can be a barrier and to have something right there on the page is really helpful,” he said.


According to Pettigrew, the publishing house chose to develop it for the iPad because it is the dominant tablet platform in schools, but he said they are considering Android and Windows 8 apps in the future.


Four more apps including “Twelfth Night,” “A Midsummer’s Night Dream,” “Hamlet” and “Othello” are due to be released in coming months. They are available worldwide for $ 13.99 each.


Pettigrew said the app is vetted for accuracy by experts and includes ancillary material, which is designed to augment the original text.


“To borrow a Shakespeare phrase, ‘the play’s the thing.’”


(Editing by Patricia Reaney and David Gregorio)


Gadgets News Headlines – Yahoo! News



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Dog Tumors May Give Clues for Human Breast Cancer
















Luke Robinson never liked dogs much until an ex-girlfriend offered him a puppy while he was living in San Antonio, Texas. The Great Pyrenees he named Malcolm changed all that.


“It was the first dog of my adult life,” said Robinson, 41. “He was my companion, my mate.”













But at the age of 6, Malcolm was diagnosed with bone cancer — which both devastated and mobilized Robinson.


When a veterinarian from a major university couldn’t tell Robinson why Malcolm got cancer at such young age, he went on a national crusade to “find out why.”


Robinson walked 2,300 miles over two years to raise awareness, founding in the process Two Million Dogs, an organization that is a pioneer in the field of comparative research — finding common links between animals and humans who have cancer.


Today, a $ 50,000 grant from the organization is funding such research at Princeton University to learn how breast cancer tumors progress from seemingly benign to malignant ones.


“We are using new model — no one looked at progression this way,” said Olga Troyanskaya, the computational biologist who is leading the genetic research. “It’s something that is really out there and forward-thinking.”


Troyanskaya is collaborating with Karen Sorenmo, an oncologist at the Ryan Veterinary Hospital at the University of Pennsylvania, who has a special interest in mammary tumors.


The pair met when Troyanskaya‘s German shepherd Jessie was diagnosed with terminal cancer in 2006, and she sought help from Sorenmo.


Sorenmo provided the Princeton project with tumors from shelter dogs that get free treatment from shelter dogs.


Dogs have multiple mammary glands and when they develop cancer, unlike humans, they can have multiple tumors.


“The screening is not as good, but when found, on average they have seven masses at different stages of development,” said Troyanskaya. “Some are benign … but they are not truly benign.”


Troyanskaya compares dog and human tumors on a molecular level and hopes to find genetic markers that can give clues to how human breast cancer tumors progress and which ones are more likely to become malignant.


“We are looking at progression in a unique model,” she said. “Way more research has been done in mice … Dogs get these tumors naturally and the physiology is more similar, the way tumors rise is similar, with the hormonal link to breast cancer in women.”


Troyanskaya said she hopes to find targets for drug treatment or predict clinical outcomes in women with breast cancer and help speed up human trials.


“We can help dogs and humans,” she said.


Robinson has been the visionary in this comparative research. His own journey began in 2006 when his dog Malcolm’s cancer had spread to his lungs. Even medical experts at Tufts University could not explain to Robinson why such a young dog would be so sick.


“I took great care of him and learned everything about caring for a dog,” he said. “I did everything I was told to do.”


Malcolm died, but two years later, in 2008, the questions still gnawed at Robinson. So he dropped out of the world of finance, put all his belongings in storage and set out to walk across 16 states with two new healthy dogs, Hudson and Murphy.


“My goal was to share Malcolm’s story,” he said. And along the way, he consulted with veterinary experts to know why his dog died.


“I didn’t have a choice,” said Robinson. “He was my boy and he changed my life fundamentally. Some people continue on the same course. For me, it was life-defining.”


In 2010, he set up Two Million Dogs, believing that dogs, who live in the same environment as humans, can give clues to why humans get cancer.


“They are like the canary in the coal mines — we drink the same water,” said Robinson.


Today, Robinson is still homeless and jobless, but a tireless advocate for comparative research.


The organization he founded for sponsors is called “Puppy-Up Walks” — similar to the fundraising efforts for the Susan G. Komen for the Cure foundation and hosted in in 40 cities around the country.


Sadly, Robinson’s Great Pyrenees, Murphy, died of nasal cancer in June. And now, the man who never thought he would fall in love with a dog has a new puppy, Indiana.


“Before,” he said of Malcolm, “I didn’t know I could have a spiritual connection with an animal.”


Also Read
Diseases/Conditions News Headlines – Yahoo! News



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UK service sector growth ‘slows’

















Activity in the UK service sector grew at its slowest pace in almost two years in October, a survey has suggested.













The PMI services index from Markit/CIPS fell to 50.6 from 52.2 in September. Any score above 50 indicates growth.


Growth in new business eased, while employment in the sector fell for the second consecutive month, Markit said.


The figure was a reminder of the tough underlying economic conditions despite last month’s better-than-expected growth figures, it added.


Official figures showed that the UK economy grew by 1% between July and September, ending a nine-month long recession.


Bank meeting


“The latest UK services PMI data provide a warning to those who saw the strong growth in the GDP in the third quarter as symbolising the start of a strong and speedy economic recovery,” said Markit economist Andrew Harker.


“The expectation among firms is for activity to improve over the coming year, but the road to full economic recovery still looks to be a long one.”


Last week, the PMI survey for manufacturing indicated that the sector shrank in October for the sixth month in a row, while the survey of the construction sector found that while output was slightly higher, new work and employment shrank.


Analysts said the weaker-than-expected services PMI reading increased the possibility that the Bank of England might increase its programme of quantitative easing (QE), which has now reached a level of £375bn, when its monetary policy committee (MPC) meets later this week.


Under QE, the Bank buys government bonds, hoping to create beneficial knock-on effects for the economy.


“It does raise the risk of further QE from the Bank. On balance, though, we think it probably won’t, given the risk of inflation,” said George Buckley at Deutsche Bank.


“What it does tell us is that while there have been some mixed messages, more positive than negative, we’re not seeing a very fast recovery at all.”


Vicky Redwood, at Capital Economics, said: “The MPC pays a lot of attention to this survey and this Thursday’s meeting now looks an even closer call than before.


“Given the stronger near-term outlook for inflation, we think that the chances of more QE this week are just below 50-50.”


Separately, a report suggested that the UK would be the fastest-growing major economy in Europe in the next two years. The eurozone debt crisis would drag the bloc into a second year of recession, the Centre for Economics and Business Research (CEBR) said.


While the eurozone economy would contract by 0.4% in 2013, the UK economy would grow by 0.8%, the think tank predicted. In 2014, the CEBR said the eurozone would register growth of 0.4%, compared with the UK’s 1.4%.


BBC News – Business



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Brazil’s ‘pop-star priest’ gets mammoth new stage

























SAO PAULO (AP) — Brazil‘s “pop-star priest” is already packing in the crowds at the newly opened mammoth sanctuary that he built for his campaign to stem the exodus of faithful from the Roman Catholic Church in Latin America’s biggest nation.


Brazil still has more Catholics than any other country in the world, with about 65 percent of its 192 million people identifying themselves that way in the 2010 census. But that is down from 74 percent in 2000 and is the lowest since records began tracking religion 140 years ago.





















That’s where Father Marcelo Rossi‘s Mother of God sanctuary comes in. The not-yet-finished structure will seat 6,000 people and have standing room for 14,000 more, church leaders say. In addition, the grounds outside can hold 80,000 people who could watch Mass on outdoor video screens.


After the inaugural Mass on Friday attracted upward of 50,000 people, a beaming Rossi told reporters: “They couldn’t all fit in. There was a crowd that had to stand outside! That’s a sign we’re on the right path, and it’s this sanctuary.”


Similar numbers jammed into the huge church Saturday.


It’s a fitting stage for Rossi, a Latin Grammy-nominated singer who is known for tossing buckets of holy water on worshippers and performing rollicking Christian songs backed by a blasting live band during Mass.


The church sits on 323,000 square feet (30,000 square meters) of land. Church officials declined to confirm how big the actual building is, though local reports put it at 91,500 square feet (8,500 square meters). That would make it one of the world’s 10 biggest churches. A cross soaring 138 feet (42 meters) into the air is the focal point.


The Mother of God sanctuary is anything but traditional. Designed by noted Brazilian architect Ruy Ohtake, it has a wide-open layout giving it the feel of a warehouse. Concrete walls hold up a sloping blue roof that from the outside looks more like a basketball arena than a house of worship. With the church several years away from completion, white plastic chairs were in the place of pews for a lucky few thousand to grab a seat. The rest had to stand.


Rossi dismisses the idea his huge church is a response to the explosion of the evangelical Christian faith in Brazil. Rather, the priest seems to be battling what recent studies indicate is Catholicism’s biggest enemy: indifference.


While millions of Brazilian Catholics joined Pentecostal congregations in the 1990s, a study conducted last year by Brazil’s Getulio Vargas Foundation based on census data found that the Catholics leaving the church these days are mostly becoming nonreligious. Experts have said the trend of Brazilians deciding organized religion isn’t for them poses a more potent threat to Catholic leaders than losses to the Pentecostals.


Rossi chose to open his new church on the Brazilian holiday of Finados, the nation’s version of the Day of the Dead. “A day, a day that was dead, was transformed!” the priest told worshippers during the service, using his gold-plated microphone.


The “pop-star priest” is seen by Brazilian Catholicism as its biggest weapon against the lack of interest, and his new sanctuary adds to his tools of best-selling books and music recordings to keep worshippers interested in what many complain has become a staid institution.


There was nothing stale about his Mass on Friday.


Singing as loud as they could, waving white hankies and swaying with a rocking band, the 20,000 people who jammed into the Mother of God sanctuary hammed it up for TV cameras and shed tears down their cheeks as their superstar priest waved to them from the pulpit. An estimated 30,000 other people had gathered outside, where young boys climbed up into nearby trees trying to get a glimpse of the church grounds as they squinted over a sea of heads streaming out of the sanctuary.


“We have problems, everyone has problems,” worshipper Zuleima de Oliveira Sales said as she stood in the tightly packed sea of people under the soaring blue roof of the structure, her voice choking. “They don’t come to an end, but I have faith, I have faith in Our Lady.”


That’s the sort of belief the Catholic Church is counting on in Brazil and other developing nations. Leaders from the Vatican on down are looking to them as bulwarks against losses in Europe and the U.S., where sex abuse scandals have inspired many people to leave the church. About half of the world’s Catholics live in Latin America.


Pentecostalism was once seen as a major threat to Brazil’s Catholic Church. Pentecostal churches, many of them founded by U.S. evangelicals, saw their membership double to more than 12 percent of the country’s population over the 1990s, with about half of the congregants estimated to be former Catholics.


During the 1990s, Brazil’s economy suffered from hyperinflation and other woes, and Pentecostal churches aggressively recruited in the slums and poor outskirts of Brazil’s cities by offering nuts-and-bolts self-improvement advice as well as Christian ministry.


Since 2003, however, Pentecostal churches have seen growth slow. The percentage of Brazilians calling themselves Pentecostals edged up from 12.5 percent of the population to 13.3 percent.


Yet the Catholic Church has continued to lose parishioners, and church leaders have had little success so far in halting that trend.


Brazil was the first nation outside Europe that Pope Benedict XVI visited, during a five-day tour in 2007 largely aimed at stopping losses in Latin America. During the trip, the pope canonized Brazil’s first native-born saint.


Then Benedict announced last August during the church’s World Youth Day, which drew 1.5 million people to Spain, that the next version of the gathering would be held in Rio de Janeiro in 2013. The pope is expected to attend.


For now, Rossi hopes his big church will bring together tens of thousands of faithful for every Mass, giving new energy to the Catholic faith.


“People want big spaces. They want grand places for prayer,” he told the Globo TV network. “One candle illuminates, 10 candles illuminate — and 100,000 candles light up so much more.”


Latin America News Headlines – Yahoo! News



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Red Cross’ App Helps Sandy Victims

























App Name: Hurricane by The American Red Cross


Price: Free





















Available Platforms: iPhone, iPod Touch, iPad, (requires iOS 4.2 or later), and Android


What does this app do? Millions remained without power and the death toll in New York City topped 41 in the wake of Hurricane Sandy as of Friday morning, according to ABC News. Homes and businesses were wrecked as a result of the superstorm, with many people occupying shelters. Cleanup and recovery from Sandy will be slow and hard going for many. For those with power, or at least a charged mobile device, the Hurricane by American Red Cross app can help.


The app, although updated more than two months ago and, therefore, not exactly new, could not be more relevant than right now. Everything from its location-based alerts to its tips and checklists for planning for an emergency aims to prepare and assist those affected directly or indirectly by disaster.


The layout for this app is simple, with a string of informational buttons lining a row at the bottom. Tap on the “prepare” tab to peruse tips for planning ahead, such as what to put into an emergency kit or to learn about the evacuation plan for a particular community. The app will also alert you to warnings and storms based on locations you have selected and allow you to share those alerts with others through email. Select the “shelters” button to view and get directions to the open Red Cross shelters in your area.


On the upper-left-hand corner, the app displays a toolkit button. Select this icon to create a list of contacts as well as meeting points both within and outside of your neighborhood and share these with others in case of an emergency or evacuation.


Finally, and perhaps most importantly, tap on the “more” button, and then select “donate.” You can make a contribution to the Red Cross’s efforts via e-mail, iTunes or text.


Is it easy to set up? Download this free app and go for it.


Should I try it? This is an information-rich app with a lot of useful features. The best parts of it include the ability create a plan and share this with the people you love as well as the ability to send the “I’m safe” message via Twitter, Facebook and email.


Also Read
Wireless News Headlines – Yahoo! News



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AnnaLynne McCord to get “Scorned” With Billy Zane in new thriller

























LOS ANGELES (TheWrap.com) – AnnaLynne McCord is about to become a woman “Scorned.”


“90210″ star McCord has signed on for the revenge thriller “Scorned,” alongside “Titanic” star Billy Zane and Viva Bianca from Starz’s “Spartacus.”





















McCord and Zane will play Sadie and Kevin, a couple whose romantic weekend at a lake house takes a sideways turn when a text message from Sadie’s best friend (played by “Bianca”) to Kevin reveals a lurid love affair between the two, sending Sadie on a vengeance spree.


“Scorned” will be directed by Mark Jones, the creator and director of the beloved “Leprechaun” horror-movie series.


Jones likened the project to “sophisticated” thrillers such as “Fatal Attraction” and “Misery.”


“Having done horror with comedy, I wanted to delve into something more sophisticated along the lines of ‘Fatal Attraction’ and ‘Misery,’ and develop a multi-dimensional, twisted character in our lead villain (McCord), who I feel brings an original and incredibly unique take on her character,” Jones said.


Lightning Entertainment will handle international sales of the film, with Lightning’s Audrey Delaney and Marc Bienstock executive-producing.


Movies News Headlines – Yahoo! News



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Anorexic Bakes to Gain Control Over Food

























Camilla Kuhns of Kirkland, Wash., makes the best cookies in the world. Ask anyone but her.


Kuhns is a 29-year-old anorexic with a penchant for baking. She has never tasted one of her own confections. Her younger brother, Seth, samples dough and final products to let her know if anything is off, and her mother, Ilene, tastes the frosting.





















“Yeah, my mom’s my angel when it comes to the frosting,” Kuhns told ABC News Seattle affiliate KOMO-TV right before she entered an inpatient treatment program for her eating disorder two weeks ago. “I don’t know what it is, but it makes me very anxious.”


On her blog, Kuhns said she is 5’8″ and weighs 104 pounds with her shoes and clothes on and while holding her purse. She baked challah breads, cakes and pastries for others to enjoy while her own daily intake amounted to a head of cauliflower with hot sauce and a tablespoon of nuts. To ensure she burned off every single calorie consumed, she exercised for three to four hours a day.


Her best friend, Amber “Nic” Poppe, said that Kuhns has suffered from various eating disorders since she was 11. Both her anorexia and the baking escalated recently after a tough year that included the death of a friend and a messy divorce.


“Baking became therapeutic for her. I know it sounds strange but it seems like her way of overcoming her issues with food,” Poppe said.


Actually, it isn’t so strange. Experts have long noted the connection between eating disorders and baking, as well as cooking, watching cooking shows and collecting recipes.


In a famous 1943 study known as the Minnesota Starvation Experiment, men put on a semi-starvation diet for six months developed such an intense obsession with food, they daydreamed, read and talked about it constantly. The fixation was so persistent that more than 40 percent of them mentioned cooking as part of their post-experiment plans. After they left the study and regained their weight, three of the men changed their occupations to become chefs.


“I see it a lot this in my practice,” said Jennifer Thomas, an assistant psychologist at the Klarman Eating Disorders Center at McLean Hospital in Boston. “Patients will prepare elaborate meals for friends and family while they themselves go hungry. They get a vicarious joy and a sense of superiority from watching others indulge while they don’t allow themselves to eat.”


As someone who was anorexic for five years, Victoria Casciaro said she can relate. The 20-year-old college student admitted she was also a starving baker who constantly made treats she never considered eating herself.


“I would look at what I put in the mixing bowl and it would scare me because I didn’t have the nutrition facts, so I couldn’t calculate whether or not it was a safe or dangerous food,” she recalled.


Not only would Casciaro resist her sumptuous creations, she would wash her hands frequently during the baking process to prevent herself from accidentally tasting the ingredients. She’d carefully avoid taking even the tiniest nibble for fear that she’d gain weight or set off a binge.


Haley Anderson, a 20-year-old recovering anorexic, said she’d often whip up copious amounts of baked treats for everyone else, then talk herself out of trying them.


“I’d tell myself that taste buds have memory,” she said, “and if you can avoid a certain food long enough then you could forget what it tastes like and no longer be tempted by it.”


Health News Headlines – Yahoo! News



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Comet gift vouchers are suspended




























Comet customer: “It looks like a plague of locusts have been inside [the store] and cleaned the place out”



The administrators of the electrical retailer Comet have suspended the use of gift vouchers at the stores.


The shops have been open as usual over the weekend since administrators were called in on Friday.


The Comet website has returned in a slimmed down form, confirming store locations and answering questions about the administration.


There has been no sign of heavy discounting so far, but the website said a sale would be starting soon.


On the question of gift vouchers, it said: “The administrators are currently considering the position in relation to gift cards and gift vouchers and at this stage they cannot be used to pay for items.


“The administrators are reviewing this position urgently.”


Holders of gift vouchers would usually be considered as low priority creditors to a retailer going into administration, and would be unlikely to be able to use their vouchers.


The exception is when a chain is sold to new owners, who might decide to accept them as an act of goodwill to prevent the brand they have bought being tarnished.


The new website explained on its front page that administrators from Deloitte had been appointed.


Its question and answer section said that people who were waiting for items to be delivered that they had paid for would only be receiving those items if they were already in stock at a delivery centre.


“Where the item for an existing order is not currently in stock, this delivery cannot now be made,” it said.


BBC News – Business



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