Oncothyreon lung cancer drug fails in late-stage trial






(Reuters) – Biopharmaceutical company Oncothyreon Inc said a late-stage trial of its experimental lung cancer drug did not meet the main study goal of improving overall survival.


The drug, codenamed L-BLP25, is being tested in patients with unresectable, locally advanced stage IIIA or stage IIIB, non-small cell lung cancer (NSCLC).






The trial was conducted by Merck Serono, a division of Germany’s Merck KGaA, under a license agreement with Oncothyreon.


(Reporting by Esha Dey in Bangalore; Editing by Roshni Menon)


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UBS fined $1.5 billion in growing Libor scandal






ZURICH (Reuters) – Swiss bank UBS admitted fraud and accepted a $ 1.5 billion fine on Wednesday for its role in manipulating global benchmark interest rates.


Dozens of UBS staff rigged the Libor rate, which is used to price trillions of dollars worth of loans, in collusion with brokers and traders at other banks, according to an investigation by authorities in multiple countries.






The controversy is expected to ensnare other big lenders and spark criminal and civil lawsuits against individuals involved. The penalty UBS agreed with U.S., UK and Swiss authorities far exceeds the $ 450 million levied on Britain‘s Barclays in June, also for rigging Libor, and the second largest ever imposed on a bank.


“This is an endemic banking industry problem and shows how far the industry has fallen, failing itself and its customers,” said Neil Dwane, chief investment officer for Allianz Global Investors.


“For the future it shows that without strong regulation and strong and new management throughout most of the biggest banks, there can be no reasonable expectation that they will improve their behavior substantially – at least UBS now has strong new management.”


Shares in the Swiss lender rose 1.6 percent to hit a 17-month high of 15.5 francs ($ 16.97) in early trade as investors judged the worst was over.


“You can see from the stock movement that the fine is already baked in,” said Markus Jordi, principal at Zurich-based investment manager Cosmos Capital.


“The bank has already kicked out some traders, apologized, said it will shut down parts of the investment bank and overhauled management.”


The UBS fine comes a week after Britain’s HSBC agreed to pay a record $ 1.92 billion to settle a probe in the United States into laundering money for drug cartels.


UBS’s unit in Japan pleaded guilty to one count of fraud relating to manipulation of benchmark rates, including the yen Libor.


The Libor benchmarks are used for trillions of dollars worth of loans around the world, ranging from home loans to credit cards to complex derivatives.


Tiny shifts in the rate, compiled from daily polls of bankers, could benefit banks by millions of dollars. But every dollar a bank benefited meant an equal loss by a bank, hedge fund or other investor on the other side of the trade – raising the threat of a raft of civil lawsuits.


REPUTATIONAL HIT


The Libor settlement caps a torrid 18 months for UBS during which it lost $ 2.3 billion in a rogue trading scandal, underwent a management upheaval and made thousands of job cuts.


“We deeply regret this inappropriate and unethical behavior. No amount of profit is more important than the reputation of this firm,” UBS Chief Executive Sergio Ermotti said in a statement.


The reputational impact of the controversy may only emerge next year.


“The only thing shareholders can do is keep a very close eye on the money flows on the wealth management side,” said Neil Wilkinson, portfolio manager at Royal London Asset Management.


“We may not see until the first quarter of next year whether they have lost any clients as a result of this.”


Ermotti said around 40 people had left UBS or had been asked to leave as a result of the investigation.


The bank will pay $ 1.2 billion to the U.S. Department of Justice (DoJ) and the Commodity Futures Trading Commission (CFTC), 160 million pounds to the UK’s Financial Services Authority (FSA) and 59 million Swiss francs from its estimated profit to Swiss regulator Finma.


The UK penalty is the largest in the history of the FSA and more than double the 59 million pounds paid by Barclays.


UBS said the fines would widen its fourth quarter net loss but it would not need to raise new capital.


BE A HERO


Britain’s FSA said attempts to manipulate Libor and Euribor, its European equivalent, were so widespread that every submission UBS made over a six-year period from 2005 to 2010 was suspect.


At least 45 people at UBS were involved in the rigging, which was discussed in internal chat forums and group emails but never detected by compliance staff, despite five audits.


The FSA said the manipulation was considered to be “normal business practice” by a wide pool of people within UBS.


In addition to traders trying to move the Libor rate up or down to make money for themselves, senior managers at the Swiss bank directed dealers to keep Libor submissions low during the financial crisis to make the bank look stronger.


The extent of the wrongdoing was highlighted in a series of emails released by the FSA which showed how traders and brokers conspired to rig the rate and referred to each other in congratulatory terms such as “superman” and “be a hero today”.


In one email, a trader wrote :”I need you to keep it as low as possible … if you do that …. I’ll pay you, you know, 50,000 dollars, 100,000 dollars… whatever you want … I’m a man of my word”.


It is the first time that brokers have been accused of taking payments to aid manipulation. ICAP, the world’s largest inter-dealer broker, and rival RP Martin have suspended employees in connection with the probe.


In a memo to staff on Wednesday, Ermotti said it was too early to determine whether or how clients were affected, pending further regulatory probing of the rate fixing.


Last week, British police arrested three men, including former UBS and Citigroup trader Thomas Hayes, in connection with the Libor probe, the first such arrests. The two others were Terry Farr and James Gilmour, who both worked at interdealer broker RP Martin.


Until the rate-rigging scandal broke, Libor had been ignored by regulators and left to the banks to police. From next year, Britain’s FSA will have oversight of it as part of a major overhaul.


The steep fine for UBS is despite the bank, since 2011, cooperating with law-enforcement agencies in their probes. The bank said it received conditional immunity from some regulators.


A similar admission by Barclays in June touched off a political firestorm that forced its chairman and chief executive to quit.


(Additional reporting by the Zurich bureau and London bureau; Writing by Carmel Crimmins and Alex Smith. Editing by Anna Willard and Janet McBride)


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Syrian rebels take control of Damascus Palestinian camp






BEIRUT (Reuters) – Syrian rebels took full control of the Yarmouk Palestinian refugee camp on Monday after fighting raged for days in the district on the southern edge of President Bashar al-Assad‘s Damascus powerbase, rebel and Palestinian sources said.


The battle had pitted rebels, backed by some Palestinians, against Palestinian fighters of the pro-Assad Popular Front for the Liberation of Palestine-General Command (PFLP-GC). Many PFLP-GC fighters defected to the rebel side and their leader Ahmed Jibril left the camp two days ago, rebel sources said.






“All of the camp is under the control of the (rebel) Free Syrian Army,” said a Palestinian activist in Yarmouk. He said clashes had stopped and the remaining PFLP fighters retreated to join Assad‘s forces massed on the northern edge of the camp.


The battle in Yarmouk is one of a series of conflicts on the southern fringes of Assad’s capital, as rebels try to choke the power of the 47-year-old leader after a 21-month-old uprising in which 40,000 people have been killed.


Government forces have used jets and artillery to try to dislodge the fighters but the violence has crept into the heart of the city and activists say rebels overran three army stations in a new offensive in the central province of Hama on Monday.


On the border with Lebanon, hundreds of Palestinian families fled across the frontier following the weekend violence in Yarmouk, a Reuters witness said.


Syria hosts half a million Palestinian refugees, most living in Yarmouk, descendants of those admitted after the creation of Israel in 1948, and has always cast itself as a champion of the Palestinian struggle, sponsoring several guerrilla factions.


Both Assad’s government and the mainly Sunni Muslim Syrian rebels have enlisted and armed divided Palestinian factions as the uprising has developed into a civil war.


“NEITHER SIDE CAN WIN”


Syrian Vice President Farouq al-Sharaa said in a newspaper interview published on Monday that neither Assad’s forces nor rebels seeking to overthrow him can win the war.


Sharaa, a Sunni Muslim in a power structure dominated by Assad’s Alawite minority, has rarely been seen since the revolt erupted in March 2011 and is not part of the president’s inner circle directing the fight against Sunni rebels. But he is the most prominent figure to say in public that Assad will not win.


Sharaa said the situation in Syria was deteriorating and a “historic settlement” was needed to end the conflict, involving regional powers and the U.N. Security Council and the formation of a national unity government “with broad powers”.


“With every passing day the political and military solutions are becoming more distant. We should be in a position defending the existence of Syria. We are not in a battle for an individual or a regime,” Sharaa was quoted as telling Al-Akhbar newspaper.


“The opposition cannot decisively settle the battle and what the security forces and army units are doing will not achieve a decisive settlement,” he said, adding that insurgents fighting to topple Syria’s leadership could plunge it into “anarchy and an unending spiral of violence”.


Sources close to the Syrian government say Sharaa had pushed for dialogue with the opposition and objected to the military response to an uprising that began peacefully.


In a veiled criticism of the crackdown, he said there was a difference between the state’s duty to provide security to its citizens, and “pursuing a security solution to the crisis”.


He said even Assad could not be certain where events in Syria were leading, but that anyone who met him would hear that “this is a long struggle…and he does not hide his desire to settle matters militarily to reach a final solution.”


In Hama province, rebels and the army clashed in a new campaign launched on Sunday by rebels to block off the country’s north, activists said.


The Syrian Observatory for Human Rights, an opposition-linked violence monitor, said fighting raged through the provincial towns of Karnaz, Kafar Weeta, Halfayeh and Mahardeh.


It said there were no clashes reported in Hama city, which lies on the main north-south highway connecting the capital with Aleppo, Syria’s second city.


Qassem Saadeddine, a member of the newly established rebel military command, said on Sunday fighters had been ordered to surround and attack army positions across the province. He said Assad’s forces were given 48 hours to surrender or be killed.


In 1982 Hafez al-Assad, father of the current ruler, crushed an uprising in Hama city, killing up to 30,000 civilians.


Qatiba al-Naasan, a rebel from Hama, said the offensive would bring retaliatory air strikes from the government but that the situation is “already getting miserable”.


(Additional reporting by Oliver Holmes, Erika Solomon and Dominic Evans in Beirut, Afif Diab at Masnaa, Lebanon; editing by Philippa Fletcher)


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Iran leader gets the clicks with Facebook rumor






DUBAI, United Arab Emirates (AP) — A Facebook page purportedly created by Iran‘s Supreme Leader Ayatollah Ali Khamenei attracted nearly 10,000 followers on Tuesday although the site’s content and style raise serious questions about its authenticity.


Iranian authorities had no immediate comment on the site, which apparently went online last week but only recently gained prominence among social media watchers. Despite the possibility that it is a hoax, the page has generated at least 170 comments — laudatory and derogatory, and nearly all in Farsi — that highlight the deep political divisions in Iran and possibly opposition fervor from expatriate Iranians.






One post compared Khamenei to a celebrated ruler of ancient Persia, Cyrus the Great, who significantly expanded the Persian empire 2,500 years ago.


Another wrote: “Mr. Khamenei, how are you visiting this page? With proxy?”


It was a reference to Iran’s blocking of Facebook and many other Western social media sites, and the efforts to bypass the restrictions using proxy server links from outside Iran.


The U.S. State Department said Monday it will keep tabs on the page, but had no comment on whether it was genuine or not. Spokeswoman Victoria Nuland joked that Washington is curious how many “likes” the Khamenei page receives.


But much about the page — including an informal photo of Khamenei riding in a car — suggested it was not sanctioned by Iran’s top leader. It is also highly unlikely that Khamenei would endorse a banned outlet such as Facebook.


The Net is not unknown territory for Iranian leaders, however. Khamenei, President Mahmoud Ahmadinejad and others have official websites. Also, some senior Iranian clerics issue religious opinions by email.


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“The Office” head Greg Daniels sells tennis comedy to Fox






LOS ANGELES (TheWrap.com) – “The Office” might be preparing to close up shop, but the series’ creator is most definitely still open for business.


Greg Daniels, who birthed the American version of “The Office” – which is preparing to wrap up its run at the end of this season – has sold a half-hour comedy to Fox via Universal Television and his own Deedle-Dee Productions.






The project was sold through Daniels by Tom Gormican (“Are We Officially Dating?”) and Richie Keen (“It’s Always Sunny in Philadelphia”), who are also writing.


The as-yet-untitled project will revolve around Richie, a so-so tennis pro who returns to his college town to get a fresh start on life. There, Richie finds himself torn between living the carefree life with his bar-owning brother and growing up to pursue Kristen, the love of his life.


Daniels will executive-produce the project via his Deedle-Dee Production, along with Gormican and Keen.


Deedle-Dee’s Howard Klein and Tracy Katsky are also executive-producing, along with Oly Obst.


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Saudi Arabia bans Brazil beef imports on mad cow doubts






SAO PAULO (Reuters) – Saudi Arabia has suspended imports of Brazilian beef, Brazil‘s agriculture ministry said on Tuesday, and became the largest country to stop purchases after confirmation of a 2010 case of atypical mad cow disease.


The decision, confirmed by a ministry press official in Brasilia, follows Egypt‘s ban of beef on Monday from Parana state, where a cow that died two years ago had developed atypical bovine spongiform encephalopathy (BSE), or mad cow disease. Egypt will continue to import from other states.






Between January and October, Saudi Arabia imported 31,300 metric tons of beef, putting it among the top 10 largest importers from Brazil, the world’s largest beef exporter.


But top buyers Russia, Hong Kong and Egypt – which took more than half of the 896,000 metric tons of beef that Brazil has exported this year through September – continue to import its beef, suggesting the impact could be limited.


Prior to Saudi Arabia, only Japan, China and South Africa had halted imports of all Brazilian beef since Brazil announced on December 7 that a 13-year-old cow that died in 2010 in Parana tested positive for the protein linked to the development of BSE.


The countries are all minor importers of Brazilian beef.


The cow, which was kept for breeding purposes, never developed BSE and died of other causes. But it tested positive for the causal agent for BSE, a protein called a prion, which can arise spontaneously in elderly cattle.


A similar case of atypical BSE occurred in the United States in April. Like the Brazilian cow, that animal never entered the food chain and there was no major effect on U.S. beef exports.


Brazilian companies like JBS SA,, the world’s biggest meats producer, as well as rival Minerva SA and food processor Marfrig Alimentos SA have played down the impact of the case on their operations.


After it confirmed the case of atypical BSE, the World Animal Health Organization issued a statement maintaining Brazil’s status as a low-risk country for mad cow disease.


“This classification has been followed by important countries, blocks and consumers,” Minerva said in a statement on Tuesday, adding that sales to Saudi Arabia accounted for approximately 2.5 percent of gross sales so far this year.


(Reporting by Patricia Monteiro and Roberto Samora; Writing by Caroline Stauffer; Editing by Jeffrey Benkoe)


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TSX may open higher on “fiscal cliff” hopes






(Reuters) – Toronto’s main stock index looked set to open higher on Tuesday, tracking global markets, fueled by expectation that U.S. lawmakers might reach an agreement to avoid looming tax increases and spending cuts that threaten to hurt the world’s biggest economy.


TOP STORIES






* The differences over how to resolve the “fiscal cliff” narrowed significantly Monday night as President Barack Obama made a counter-offer to Republicans that included a major change in position on tax hikes for the wealthy, according to a source familiar with the talks.


* Knight Capital Group’s board was split between two competing offers for the firm after a meeting on Monday where suitors Getco Holding Company LLC and Virtu Financial LLC presented their sweetened bids to Knight’s directors, sources involved in the talks said.


* British inflation defied forecasts in November to hold at its highest rate since May, reducing the scope for the Bank of England to inject more cash into the struggling economy.


* Germany’s government is considering cutting its forecast for growth in Europe’s largest economy next year from its current estimate of 1 percent due to a weak half year over the winter, Deputy Economy Minister Bernhard Heitzer told Reuters.


MARKET SNAPSHOT


* Canada stock futures traded up 0.26 percent


* U.S. stock futures,, were up around 0.40 percent <.n></.n>


* European shares <.fteu3>, <.stoxx> were up <.eu></.eu></.stoxx></.fteu3>


COMMODITY PRICE MOVES


* Thomson Reuters-Jefferies CRB Index <.trjcrbtr>: 295.92; was up 0.13 percent</.trjcrbtr>


* Gold Futures: $ 1,699.3; up 0.06 percent


* US Crude: $ 87.70; up 0.54 percent


* Brent Crude: $ 108.23; up 0.55 percent


* LME 3-month Copper: $ 8,028.25; fell -0.43 percent


ANALYST RECOMMENDATIONS


Following is a summary of research actions on Canadian companies reported by Reuters.


* AuRico Gold Inc. : BMO resumes coverage with market perform rating, raises price target to C$ 9.50 from C$ 9, after the company completed the sale of its Ocampo project and announced a share buyback program


* First Majestic Silver : Raymond James cuts target price to C$ 26 from C$ 26.75 after the company said it would acquire Orko Silver Corp in a share and cash deal worth C$ 345 million


* Kirkland Lake Gold Inc. : CIBC cuts target to C$ 9 from C$ 15 citing the challenges at the company’s Macassa operations and its greater-than-expected outlook cuts


* Primero Mining Corp.


: RBC cuts target to $ 8.50 from $ 9 after the company said it would acquire Cerro Resources, giving it an element of growth in 2015


* Sun Life Financial Inc. : Canaccord Genuity cuts to sell rating on valuation while CIBC ups target to C$ 26 from C$ 25 after the company said it would sell its U.S. annuities business for $ 1.35 billion


ON THE CALENDAR


* No Major Canadian economic data scheduled for release


* Major U.S. events and data includes Redbook, NAHB index and SEMI book/bill


(Reporting by Kishan Nair)


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Iran media: Son of ex-president released on bail






TEHRAN, Iran (AP) — Iranian media say the son of influential former President Akbar Hashemi Rafsanjani has been released on bail.


Several papers, including the pro-reform Etemad daily, say Mahdi Hashemi was released late Sunday and immediately went to his father’s home.






Authorities arrested the younger Hashemi in late September, a day after he returned to Iran from Britain.


He is held on charges of fomenting unrest in the aftermath of Iran’s disputed 2009 presidential election that brought President Mahmoud Ahmadinejad a second term in office. Hashemi also faced corruption charges.


His arrest came days after his sister, Faezeh, was taken into custody to serve a six-month sentence on charges of making propaganda against Iran’s ruling system.


Since Rafsanjani backed Ahmadinejad’s reformist challenger in 2009, his family has come under pressure from hardliners.


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Modern Etiquette: A bit of netiquette will keep Christmas real






LONDON (Reuters) – Christmas is a convivial time of year when people get together for celebrations and conversation. It’s all about human contact so it’s important that you’re discriminating about how you use your digital devices.


It’s fine if they’re used to facilitate get-togethers and spread seasonal cheer. But Christmas is a real, not a virtual event, so it’s important to discard the phones, tablets and computers and enjoy festive celebrations in the real world.






Christmas cards are still an invaluable and personal way of keeping in touch with far-flung friends and relations.


In these straitened times, however, you might want to cut down the number of cards you send, so it’s fine to explain to your nearest and dearest that you won’t be sending them cards – a personalized seasonal message by text, phone call or email, sent out to individuals, is quite acceptable.


Avoid sending out generic e-cards. They’re lazy and impersonal, and many people will find them lacking in Christmas spirit or just baffling.


If you’re emailing instead of sending a Christmas card, make sure that you send out unique – and individual – messages to each of your recipients. Group emails, like round robins, are to be avoided.


It’s fine to put general seasonal messages on social networking sites, but avoid posting compromising photos.


This is the time of year when we all let our hair down, but not everyone will appreciate the evidence being posted for all to see in cyberspace.


Don’t get too carried away with seasonal cyber-cheer. Spamming your friends and followers with endless Christmas wishes and updates will soon get tedious.


Christmas Day is all about socializing with family and friends, and enjoying good food and good conversation. So don’t spend the big day glued to your phone, rather than interacting with your family.


Ban all phones from the Christmas table.


Eating together is all about sociability and it’s a real insult to the host and/or cook to be transfixed by your texts rather than the turkey and table talk.


Be a good digital host.


Technology is part of our everyday life and Christmas is no exception. If you have friends or family staying in your home, make sure that you have your WiFi password to hand. Offer them access to your network, and hope that everyone adheres to good festive netiquette.


Christmas is the perfect time to make a video call, but choose your timing carefully. Nobody wants to be talking to virtual visitors during lunch or present opening.


Remember the power of the written word.


If you are the lucky recipient of a generous present or lavish hospitality, then hand-writing a proper thank you letter is a much more elegant gesture than texting or emailing, and will be noted and appreciated. It is fine to email or text your thanks for small presents.


(This story has been refiled to fix dateline)


(Jo Bryant is an etiquette advisor and editor at Debrett’s, the UK authority on etiquette and modern manners (www.debretts.com). Any opinions expressed are her own. Debrett’s “Netiquette” is a definitive guide to digital dilemmas and outlines a code of manners for modern communication.)


(Editing by Paul Casciato)


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Amy Winehouse inquest to be heard again






LONDON (AP) — Officials in London say the inquest into the death of soul singer Amy Winehouse was overseen by a coroner who lacked the proper qualifications and will be re-heard next month.


Camden Council says a new hearing will take place on Jan. 8.






Winehouse was found dead in her London home in July 2011 at age 27. An inquest in October 2011 found the “Back to Black” singer had died of accidental alcohol poisoning.


Assistant deputy coroner Suzanne Greenaway, who oversaw the inquest, resigned the next month after her qualifications were questioned. She had been appointed by her husband, Andrew Reid, the coroner for inner north London.


Reid was suspended, and resigned earlier this month.


Winehouse family spokesman Chris Goodman said Monday that family had not requested a new hearing.


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